In stark contrast, their visitors come into this tie on the back of three straight defeats, and they will be looking to get their season up and running by grabbing all three points.
Sydney ended their four-game winless run with a 2-0 home win over Western United last Wednesday.
Steve Corica's men made it two wins from two as they fought back from one goal down to claim a 2-1 win over Newcastle Jets last time out.
The Sky Blues' resurgence has now seen them move into the playoff places, after Macarthur and Brisbane Roar fell to respective defeats last time out.
On the other hand, Melbourne Victory failed to put an end to their losing streak last time out as they suffered a 3-1 home defeat at the hands of Adelaide United.
Jake Brimmer gave the hosts the lead in the 28th minute, but the Reds replied with three goals of their own to turn the game on its head.
Grant Brebner's men have now lost three games on the bounce, including a 6-0 mauling in the Melbourne derby, and have picked up just two wins in 11 games since the turn of the year.
With seven points from 33, they are firmly rooted at the bottom of the table, four points adrift of 11th-placed Newcastle Jets.
While the Melbourne outfit will look to end this poor run on Saturday, they take on a Sydney side who have picked up five wins from their last five meetings.
Their last encounter came back in March 2020, when the Sky Blues came from one goal down to grab an emphatic 4-1 win.
Sydney have a relatively clean bill of health heading into Saturday's clash, with only a few injury concerns in the squad.
They are joined on the treatment table by Marco Rojas, who is expected to miss between six to eight weeks with a fractured fibula.
Sydney FC possible starting lineup:
Redmayne; King, Warland, Wilkinson, Grant; Brattan, Baumjohann, Ninkovic, Caceres; Barbarouses, Buhagiar
Melbourne Victory possible starting lineup:
Crocombe; Traore, Ansell, Anderson, Roux; Broxham, Butterfield; Kruse, Brimmer, McManaman; Folami
We say: Sydney FC 3-1 Melbourne Victory
While the visitors continue to struggle this season, the hosts look to have found their feet in recent weeks. Sydney have a solid record against Brebner's men, and considering their resurgence, we fancy them to comfortably grab the win on Saturday.