Sebastian Prodl is the man to make way for the Hornets, dropping to the substitutes' bench.
Stoke are unchanged from the side that defeated Swansea City 1-0 on Monday, a result that marked their fourth win on the spin in all competitions.
Stoke City: Butland; Johnson, Cameron, Wollscheid; Pieters, Adam, Whelan, Shaqiri, Krkic; Arnautovic, Joselu
Subs: Ireland, Wilson, Afellay, Van Ginkel, Walters, Given, Crouch
Watford: Gomes; Nyom, Cathcart, Britos, Ake; Capoue, Watson; Abdi, Deeney, Anya; Ighalo
Subs: Arlauskis, Prodl, Paredes, Behrami, Guedioura, Ibarbo, Diamanti
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