Nathan Redmond could not add to his impressive FA Cup tally at Wembley and was eventually replaced after 59 minutes by Che Adams, and the Scotland man will hope to start up top alongside Danny Ings, who boasts six goal contributions in five games for Southampton against Spurs.
James Ward-Prowse and Ibrahima Diallo are shoo-ins while Will Smallbone and Oriol Romeu recuperate from serious injuries, although the Saints' injury list has eased in recent weeks, with Michael Obafemi the only other occupant of the treatment room.
Kyle Walker-Peters will be keen to impress against his former club, and while Mohammed Salisu is pushing for more game time, Jan Bednarek and Jannik Vestergaard are unlikely to be displaced in defence.
Southampton possible starting lineup:
Forster; Walker-Peters, Bednarek, Vestergaard, Bertrand; Minamino, Diallo, Ward-Prowse, Armstrong; Ings, Adams