Spurs fell to a shock 3-0 defeat at the hands of London rivals West Ham United in their last home outing, but Andre Villas-Boas's men will have been buoyed by back-to-back away wins against Aston Villa and Sheriff Tiraspol respectively.
Three points against the Tigers would guarantee a place in the top four at the end of the weekend for Tottenham, but they will be without Danny Rose, Younes Kaboul and Etienne Capoue, who are all likely to miss out through injury.
Zeki Fryers is also a doubt having limped off during Thursday's win over Sheriff, while Roberto Soldado is expected to return to the starting lineup alongside Kyle Walker, Andros Townsend and Paulinho, who were all rested for the trip to Moldova.
Hull, meanwhile, will be looking to get back to winning ways after seeing a five-match unbeaten streak end against Everton last week.
Tom Huddlestone, who joined Hull from Spurs in the summer, is expected to start the match in midfield.
Possible starting lineups
Tottenham: Lloris; Walker, Dawson, Chiriches, Vertonghen; Townsend, Paulinho, Sandro, Holtby, Sigurdsson; Soldado
Hull: Harper; Rosenior, Faye, Davies, Figueroa; El Mohamady, Huddlestone, Meyler, Brady; Aluko, Sagbo
Sports Mole says: 2-0