Ronald Koeman makes three alterations to the XI that started the 1-0 defeat to Leicester City last weekend. Shane Long returns from a knee injury while Dusan Tadic is handed a start as Steven Davis and Matt Targett are out with injuries.
Southampton: Forster, Bertrand, Martina, Fonte, Van Dijk, Clasie, Wanyama, Tadic, Long, Mane, Pelle
Subs: Stekelenburg, Cedric, Yoshida, Rodriguez, Romeu, Ward-Prowse, Austin
Newcastle United: Darlow, Anita, Mbemba, Taylor, Janmaat, Townsend, Shelvey, Wijnaldum, Sissoko, Perez, Mitrovic
Subs: Woodman, Dummett, Lascelles, Tiote, Obertan, De Jong, Cisse
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