Conor Coady's hopes of making a 122nd consecutive league appearance for Wolves hang in the balance after he was forced to leave the England squad due to covid protocols.
Rayan Ait-Nouri is expected to shrug off the knock which saw him withdraw from France's under-21 squad at the start of the international break.
Captain James Ward-Prowse is expected to be fit for Southampton after he returned to training this week following a hamstring injury which ruled him out of international duty.
Wolves provisional squad: Patricio, Ruddy, Buur, Semedo, Kilman, Ait-Nouri, Marcal, Coady, Hoever, Boly, Saiss, Moutinho, Neves, Vitinha, Dendoncker, Traore, Podence, Neto, Jimenez, Silva.
Southampton provisional squad: McCarthy, Walker-Peters, Bertrand, Vestergaard, Bednarek, Romeu, Ward-Prowse, Redmond, Adams, Armstrong, Forster, Stephens, Valery, Diallo, Long, Obafemi, Walcott, Tella.