The Owls brought an end to their winless run in midweek and were given another boost with news that their 12-point deduction has been halved.
Millwall are without a goal or a win in their last two outings, meanwhile, but they are just a point outside the playoff zone ahead of this match.
If certain reports were to be believed, Garry Monk was on the brink of being sacked by Wednesday following a run of four defeats on the spin, failing to score in three of those.
Barry Bannan's second-half penalty against 10-man Bournemouth on Tuesday could prove to be the turning point for Monk though, with Wednesday stopping the rot thanks to a precious 1-0 victory.
However, not since December 2019 have the Owls won back-to-back matches in the league - the type of inconsistency that has plagued them for too long.
That win against Bournemouth, combined with their points deduction being cut in half, means that Monk's men are now three points from safety.
Clawing out of the bottom three as soon as possible will be the aim for the Yorkshire outfit, before then re-evaluating their aims for the campaign.
Millwall's target seems to be pretty clear at this stage as they find themselves just a point outside the playoff places heading into matchday 11.
The Lions played out a goalless draw against Norwich City in midweek, four days on from firing a blank in a 3-0 home loss to Huddersfield Town.
That latest shutout made it 15 clean sheets for Gary Rowett's charges in 2020 - more than any other side in the top four tiers of English football.
Millwall have also kept a clean sheet in each of their last three league meetings with Wednesday, following on from a run of 11 in a row without doing so.
The South London club do not tend to pick up wins at Hillsborough, however, losing three and drawing three of their last six trips since a 2-1 win in September 2005.
Sheffield Wednesday Championship form: WLLLLW
Millwall Championship form: WWDWLD
Monk is expected to stick with his 3-5-2 formation, with Adam Reach a contender to fill in for Harris at left wing-back.
As for the visitors, they will be without Kenneth Zohore for the next couple of months because of a calf issue.
Millwall tend to use five across the back away from home, so expect that to be the case here.
Sheffield Wednesday possible starting lineup:
Wildsmith; Palmer, Iorfa, Borner; Odubajo, Bannan, Pelupessy, Reach; Brown; Windass, Kachunga
Millwall possible starting lineup:
Bialkowski; Romeo, Hutch, Cooper, Murray, Malone; Woods, Leonard; Wallace, Bradshaw, Bennett
We say: Sheffield Wednesday 0-1 Millwall
Wednesday may have picked up an important victory in midweek, but it has been 11 months since they last won back-to-back matches in the league.
Millwall are without a goal in their last two matches but have 10 points from their five away league games so far this term - only Preston North End have earned more (13) - so we are backing the Lions to edge this one.