Both of these sides performed well in the group stage and this encounter will certainly be one to savour this weekend.
Saint Kitts and Nevis finished top of Group F after winning three of the four games and losing just one.
The nation's victories included big scorelines against Guyana and the Bahamas.
However, Saint Kitts and Nevis come into this game on the back of a 2-0 defeat to Trinidad and Tobago, the two goals were the only goals conceded by Saint Kitts and Nevis during the group stage.
Back to full strength for this tie, Saint Kitts and Nevis will look to make use of their advantage and get the better of El Salvador in this one.
El Salvador also won their group and managed to pick up some memorable wins along the way, with their 7-0 win over the U.S. Virgin Islands being the pick of the bunch.
The country won the group with ten points to their name and just one goal conceded.
Although they can shine against lesser opposition, it remains to be seen whether El Salvador can pick up good results against better teams.
St Kitts and Nevis boss Leonardo Neiva is expected to reinstate a number of key players in the side following the weakened side he fielded against Trinidad and Tobago.
Rugamas and Martinez are expected to lead the line again for La Selecta this week and will be buoyed by their performances last time out.
Zavaleta could also start at the back for Hugo Perez's side.
Saint Kitts and Nevis possible starting lineup:
Samuel; Burley, Flemming, Leader, French; Maynard, Sawyers, Somersall, Wharton; Panayiotou, Liburd
El Salvador possible starting lineup:
Gonzalez; Zavaleta, Gomez, Dominguez, Larin; Ceren, Mayen, Monterrosa, Portillo; Martinez, Rugamas
We say: Saint Kitts and Nevis 0-1 El Salvador
This will be an interesting encounter between two reasonably matched sides, but we think El Salvador probably have the upper hand coming into this tie with the superior firepower. We are going for a narrow win for La Selecta.