The hosts, meanwhile, have strung together a six-game unbeaten run in the top flight but remain just six points clear of the relegation zone.
Even though Saint-Etienne's win record this season leaves a lot to be desired, Claude Puel's men are not being put to the sword every week anymore.
A 2-2 draw with Monaco in their final game of 2020 stretched Les Verts' unbeaten run in Ligue 1 to six games, although five of those ties have ended with the spoils shared - including 0-0 and 2-2 draws with basement teams Dijon and Nimes respectively.
A 2-1 triumph at Bordeaux is the outlier in that sequence, and Saint-Etienne's position in the table is still volatile heading into the midway point of the season.
Puel's men cannot rise any higher up the table with a win on Wednesday, but defeat will open the door for Reims and Nantes - who face Dijon and Lyon respectively - to try to overtake Saint-Etienne in the congested bottom half.
Moreover, Les Verts have played out three draws in succession on home soil and are facing an uphill battle to triumph at the Stade Geoffroy-Guichard for the first time since September 12.
Not even a 4-0 thrashing of Strasbourg could save Thomas Tuchel's job in the PSG dugout, and the French champions moved quickly to replace the German over the festive period.
Pochettino has been out of management since being sacked by Tottenham Hotspur in November 2019, and the Argentine - who made 95 appearances for PSG - is sure to be aware of the mammoth task facing him in this unforgiving role.
PSG ended 2020 third in the Ligue 1 table - one point behind title rivals Lyon and Lille - but the 11 wins that the capital outfit have chalked up this term is the most in the league.
Pochettino will ultimately be tasked with leading PSG to Champions League glory, but in the short-term, the 48-year-old must endeavour to do what he failed to in five years at Spurs - win a trophy.
A fourth-straight Ligue 1 triumph is already under serious threat as the top flight prepares to resume, but a first piece of silverware could be just around the corner as PSG prepare to take on Marseille in next week's Trophee des Champions.
For now, though, Pochettino will simply look to endear himself to the PSG faithful with victory against a dogged Saint-Etienne side, whom the French champions have not lost to since November 2012.
Saint-Etienne Ligue 1 form: DDDWDD
Paris Saint-Germain Ligue 1 form: DWLWDW
Paris Saint-Germain form (all competitions): WWLWDW
Meanwhile, Pochettino could be without as many as 10 players for his first match in charge, with Neymar not expected to come back from his ankle injury just yet.
Juan Bernat is out for the long-term, and there are still question marks over the fitness of Danilo Pereira, Mauro Icardi, Abdou Diallo and Pablo Sarabia, but the latter two have outside chances of returning for this one.
Saint-Etienne possible starting lineup:
Moulin; Debuchy, Moukoudi, Kolodziejczak, Trauco; Youssouf, Gourna-Douath; Monnet-Paquet, Aouchiche, Nordin; Bouanga
Paris Saint-Germain possible starting lineup:
Navas; Marquinhos, Pembele, Kehrer; Dagba, Gueye, Herrera, Verratti, Bakker; Di Maria, Mbappe
We say: Saint-Etienne 1-2 Paris Saint-Germain
Saint-Etienne are not to be taken lightly despite winning just four matches this term, and the hosts are sure to fancy their chances with a plethora of PSG players out injured. It remains to be seen how Pochettino will line up in his inaugural game in the champions' dugout, but we still expect an injury-hit PSG team to get over the line and begin their new era in perfect fashion.