As for the visitors, they still hold small hope of overtaking AC Milan in 10th spot, but their main aim will be to ensure that they don't drop down to 13th position in the table in their first year back in the top flight.
After finally securing their Champions League place last weekend, Roma can head into their final fixture without the pressure that has followed them since the turn of the year.
At one stage this season, the Giallorossi had looked on course to feature in a two-way battle with Juventus for the Serie A title, but a run of just three wins from 16 games left the club battling for a top-three position with the likes of Lazio and Napoli.
However, after seeing Lazio close the gap over the past few weeks, Roma finally made sure of their spot in Europe's premier competition with a 2-1 victory in the derby at the Stadio Olimpico.
That win has extended their recent record to four wins from their last five matches, but despite their achievement, the club's supporters won't necessarily be impressed with sitting as many as 16 points adrift of the league leaders.
Rudi Garcia's men can afford to enjoy their last 90 minutes of the campaign, but with their boss keen to ensure that they only suffer one home defeat all season, they could relish the chance to reward their fans for keeping faith with them over the past six months.
Recent form: LWWLWW
In their first year back in Serie A, Palermo once had hopes of achieving a place in the top half of the standings, but despite that now being unlikely, they can still be satisfied with their campaign.
First and foremost, they would have wanted to avoid an immediate return to Serie B, but a winter burst of 19 points from nine games effectively guaranteed that wouldn't enter the equation.
The Rosanero have been poor since the start of the year, but it would still be a solid achievement if they can finish in 11th position.
Palermo will make the trip to the Stadio Olimpico having recorded seven points from their last four games on their travels, and with Roma perhaps playing at a lower intensity, they could capitalise to end the campaign on a positive note.
Recent form: LDDLWL
With their season effectively over, Garcia is likely to be considering changes to his starting lineup for their final 90 minutes before the summer.
Roma possible starting lineup:
De Sanctis, Holebas, Torosidis, Yanga-Mbiwa, Manolas, De Rossi, Keita, Nainggolan, Florenzi, Totti, Iturbe
Palermo possible starting lineup:
Sorrentino, Vitiello, Andelkovic, Gonzalez, Lazaar, Rigoni, Della Rocca, Jajalo, Vazquez , Quaison, Dybala
Head To Head
In 21 meetings between the two clubs, Roma have emerged victorious on 10 occasions with Palermo winning seven times.
During that period, seven of Roma's triumphs have come at the Stadio Olimpico, but they have failed to record three points in their last two away games.
We say: Roma 3-1 Palermo
Scoring goals was a problem for Roma earlier in the campaign, but having rediscovered their touch in front of goal over the past six games, it's hard to back against Garcia's team extending their recent run of form this weekend.