Juventus were feeling the pressure at the top of the table when the league returned from the winter break, but Roma have allowed the champions to build a seven-point advantage.
That is largely due to three successive draws, and there will be no excuses this weekend if Roma fail to pick up all three points when Empoli visit the Italian capital.
Playing 24 hours earlier than Juventus, who take on Udinese on Sunday, could be an advantage for Garcia's men as they look to capitalise on playing a number of Serie A's struggling sides in the coming weeks.
Roma will also begin life without Mattia Destro, who is believed to be on the verge of completing a move to AC Milan.
The meeting between the two sides comes less than a fortnight after Roma recorded a 2-1 win over Empoli in the Coppa Italia, with Daniele de Rossi scoring the crucial penalty in extra time on that evening.
Empoli head into the match severely lacking in confidence following a run of eight matches without a win in Serie A, and a wait for over two months without a victory has left them just one point above the relegation zone.
Form in Serie A: WDWDDD
Form in all competitions: DWDDWD
Possible starting lineup: De Sanctis, Holebas, Yanga-Mbiwa, Manolas, De Rossi, Strootman, Nainggolan, Pjanic, Ljajic, Totti, Iturbe
Form in Serie A: DDDLDL
Form in all competitions: DDLDLL
Possible starting lineup: Sepe, Rui, Bianchetti, Hysaj, Rugani, Croce, Valdifiori, Vecino, Saponara, Mchedlidze, Pucciarelli
Sports Mole says: 2-0