The 40-year-old is highly regarded among supporters of the capital-based outfit, having served the club with such distinction during his 10-year stint at the Stadio Olimpico.
Rudi Garcia's men head into this contest struggling for winning form, having drawn five of their last six matches in all competitions.
Against domestic rivals in European clashes, Fiorentina have won none of their four outings, while Roma have lost one and won one.
Form in Europa League: WDWLDW
Form in all competitions: DDWWWL
Possible starting lineup: Neto; Richards, Basanta, Savic, Alonso; Fernandez, Pizarro, Badelj; Salah, Joaquin; Gomez
Form in Europa League: LLLDDW
Form in all competitions: DDDWDD
Possible starting lineup: De Sanctis; Cole, Manolas, Yanga-Mbiwa, Torosidis; De Rossi, Keita; Pjanic, Gervinho, Ljajic; Totti
Sports Mole says: 1-1