Madrid will be looking to take advantage of Barcelona's defeat to Valencia yesterday, and Ancelotti's selection has reflected that desire to win as he has restored the likes of Karim Benzema, Pepe and Marcelo to the starting XI.
Bilbao, meanwhile, make just three changes to the side who were knocked out of the cup by Atletico Madrid on Wednesday as they aim to close the gap on the top three.
Athletic Bilbao: Iraizoz; De Marcos, Gurpegi, Laporte, Balenziaga; Iturraspe, Mikel Rico, Susaeta, Herrera, Muniain; Aduriz
Subs: San Jose, Benat, Kike Sola, Ibai, Iago, Iraola, Ekiza
Real Madrid: Diego López; Pepe, Ramos, Carvajal, Marcelo; Xabi Alonso, Modric, Di María; Cristiano Ronaldo, Benzema, Jese
Subs: Casillas, Varane, Coentrão, Arbeloa, Morata, Isco, Illarramendi