Zidane, who celebrates a year in charge of Los Blancos today, is without the likes of Cristiano Ronaldo, Gareth Bale, Sergio Ramos, Pepe, Lucas Vazquez and Mateo Kovacic for the first leg of the last-16 clash.
That has forced the European champions to make five changes from the side that started the final of the Club World Cup, with Kiko Casilla, Nacho, Marco Asensio, James Rodriguez and Morata all coming into the team.
Sevilla, meanwhile, make no fewer than seven changes to the side that hammed Formentera 9-1 in their last match before the winter break.
Real Madrid: Casilla; Carvajal, Varane, Nacho, Marcelo; Casemiro, Modric, Asensio, Kroos, James; Morata
Subs: Navas, Benzema, Coentrao, Mariano, Isco, Danilo, Odegaard
Sevilla: Rico; Mariano, Rami, Mercado, Escudero; N'Zonzi, Iborra, Nasri, Ganso, Vitolo; Correa
Subs: Kranevitter, Vietto, Ben Yedder, Kiyotake, Sarabia, Pareja, Sirigu
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