Getafe vs. Cadiz (Saturday, 1.00pm)
Jose Bordalas's Getafe side beat Andalusia's Yellow Submarine 2-0 in the reverse fixture in December, but Los Azulones have gone winless in their last four league games, leaving the door open for Cadiz to challenge for all three points this weekend.
We say: Getafe 1-1 Cadiz
Getafe have really lost their drive in recent weeks, and it is a sense of torpor that is contracted by the opposition too, typically resulting in humdrum stalemates that are not much use to anyone and are a hard pill to swallow for neutrals too. A couple of goals could liven this contest up, though.
Athletic Bilbao vs. Alaves (Saturday, 3.15pm)
Following the sacking of Abelardo this week, new Alaves boss Javi Calleja will preside over his first La Liga game at the helm of the club when they face their Basque rivals Athletic Bilbao at San Memes on Saturday.
Athletic come into this game with one eye on their Copa del Rey final against Barcelona next weekend; the club lost the 2020 final last weekend when Real Sociedad bested them 1-0 in a heated contest.
We say: Athletic Bilbao 2-0 Alaves
With a favourable run-in compared to their relegation rivals, Alaves stand a good chance of avoiding the drop, but we do not think a great escape will begin this weekend. Athletic are a much better side and they should comfortably pick up three points on Saturday.
Eibar vs. Levante (Saturday, 5.30pm)
Eibar boss Jose Luis Mendilibar has avoided defeat in his seven top-flight home games against Levante, but it will certainly take the Basque side a lot to come away with a point or more this weekend.
We say: Eibar 2-3 Levante
An easy game on paper for Levante is never an easy game in real life, and if there is a team in La Liga that know how to make things hard for themselves, it is Lopez's men. We are going for a dramatic 3-2 win for Levante.
Real Madrid vs. Barcelona (Saturday, 8.00pm)
One of the biggest fixtures in the football calendar will take place in the Spanish capital on Saturday evening as Real Madrid welcome Barcelona for the latest edition of El Clasico.
Los Blancos are currently third in Spain's top flight, two points behind second-placed Barca, who now trail leaders Atletico Madrid by just a single point with nine games left.
We say: Real Madrid 1-1 Barcelona
Both teams will enter this match in impressive form, and Madrid will be feeling particularly confident due to their excellent performance against Liverpool in the Champions League.
It would not be a surprise to see either a home win or an away win on Saturday evening, but a draw would not be the end of the world for either, and we can see a 1-1 being played out in the Spanish capital.