Los Blancos recorded an important 2-0 win over Inter Milan in the Champions League on Wednesday but have taken just one point from their last two league matches with Valencia and Villarreal.
Here, Sports Mole looks at how Madrid could line up on home soil.
Madrid will again be without the services of Sergio Ramos, Alvaro Odriozola and Federico Valverde this weekend through injury, while Luka Jovic's recent coronavirus positive test will rule the striker out of contention.
Karim Benzema is also still unavailable due to a groin issue, meaning that there could be another start in the final third of the field for Mariano Diaz.
Madrid confirmed on Friday that Dani Carvajal had picked up a thigh problem, but Eder Militao is available after a recent coronavirus test, meaning that the Brazilian could come into the back four, joining Nacho, Raphael Varane and Ferland Mendy.
Zidane is expected to shuffle his pack from the win over Inter, and there could be a return to the starting XI for Casemiro, with the Brazilian potentially joining Toni Kroos and Martin Odegaard in midfield.