Spanish midfielder Guti has backed his former club Real Madrid to defeat Barcelona 3-1 at the Bernabeu on Saturday evening.
Los Blancos will begin El Clasico three points ahead of rivals Barca at the top of La Liga and Guti expects that the lead will have been extended at the final whistle.
"Real Madrid will definitely beat Barcelona. I think that they will win the match 3-1," the 35-year-old told AS. "Barcelona are quite dependent on Lionel Messi. If Barca are without Messi, they usually tend to struggle.
"Real Madrid on the other hand have a fantastic squad. They have two great players in every position. If Cristiano Ronaldo is unavailable, they still have plenty of class and play some great football.
"My heart still beats for Madrid and it will always be like that. Madrid are my second family. The club has given me so much and played a big role in everything I've achieved."
Guti left Madrid in 2010 after a 16-year association with the club.