The Robins have picked up more points on their travels in the league this season, while QPR are hoping to go five matches unbeaten at Loftus Road.
QPR are the same number of points clear of the relegation zone as they are to the top six, but Warburton will be keen to ensure that the gap to the playoffs is narrowed and that they move further away from the bottom three.
The Hoops have a poor record against Tuesday's opponents, losing their last five league matches against the Robins – their worst losing run against them since 1927.
Warburton has also failed to beat Bristol City in any of his last four games as a manager, including a 3-1 defeat in 2014 when he was Brentford's boss.
Victory in midweek would be QPR's fifth of the league campaign and could move them into the top half of the table.
As a result, the Robins have slipped two places down to fifth in the Championship table and are one point clear of Brentford and Swansea City who are just behind them.
Bristol City have had success on their travels to Loftus Road in recent seasons, with the Robins winning their last two away matches against QPR – as many as in their previous 26 visits to the Hoops.
Wells scored 15 goals in 34 Championship appearances at Loftus Road for QPR between August 2018 and January 2020, and will be looking to add to that tally, albeit playing for a different club.
Bristol City, who have won five of their last eight away league matches in London, would move one point behind league leaders Norwich City with a victory on Tuesday night.
Queens Park Rangers Championship form: WWLDWL
Bristol City Championship form: LWWWDL
Midfielder Geoff Cameron, who missed Friday's loss due to a fatigue-related injury, is doubtful for Tuesday.
Winger Albert Adomah will be pushing to start against his former club, where he spend three years between 2010 and 2013.
Bristol City boss Dean Holden could revert back to a 4-3-3 formation, after lining up with a 3-5-2 setup in his previous two matches.
Queens Park Rangers possible starting lineup:
Dieng; Kakay, Dickie, Barbet, Wallace; Ball, Carroll; Osayi-Samuel, Chair, Adomah; Dykes
Bristol City possible starting lineup:
Bentley; Hunt, Vyner, Moore, Dasilva; Paterson, Nagy, O'Dowda; Semenyo, Martin, Wells
We say: Queens Park Rangers 1-2 Bristol City
Bristol City are unbeaten in their last four visits to Loftus Road, and with their sights set on closing the gap to table toppers Norwich, the Robins will have the desire to win against a side that have conceded eight goals in their last four matches.