PSG lineup vs. Barcelona: Predicted XI for Champions League clash as Luis Enrique faces injury crisis

Paris Saint-Germain head coach Luis Enrique will be missing four cornerstones of his team when the Champions League holders face Barcelona in Wednesday's league phase main event.

Les Parisiens were already without Ballon d'Or winner Ousmane Dembele (hamstring), Desire Doue (calf), Joao Neves (hamstring), Fabian Ruiz (muscle) and captain Marquinhos (thigh) for their 2-0 win over Auxerre in Ligue 1 on Saturday, where Enrique sustained two fresh concerns to another two cornerstones of his team.

Vitinha had to be withdrawn in the 33rd minute of the match with an unexplained issue, while Khvicha Kvaratskhelia was brought off during the break with a suspected hamstring problem, one that is expected to rule him out of this crunch clash.

Neves, Ruiz and Vitinha have made the squad, offering Enrique a full complement of strong midfield options, but whether any of the three are in a place to start is another question entirely.

However, none of Doue, Dembele, Kvaratskhelia or Marquinhos have boarded the plane to Catalonia, and the former trio's absence could prove fatal.

If neither Neves nor Ruiz are passed fit to start, Lee Kang-in and Warren Zaire-Emery should join Vitinha in the engine room, and Enrique may also have to put out a second-string forward line.

Dembele and Doue are not expected back until later in October, so Ibrahim Mbaye and Bradley Barcola will likely flank centre-forward Goncalo Ramos at Estadi Olimpic Lluis Companys.

In brighter news for Enrique, Achraf Hakimi, Nuno Mendes, Illia Zabarnyi and Willian Pacho are all fit and raring to go in defence, as PSG aim to become the first team to ever beat Barcelona in three successive away games in European competition.

Paris Saint-Germain possible starting lineup:

Chevalier; Hakimi, Zabarnyi, Pacho, Mendes; Lee, Vitinha, Zaire-Emery; Mbaye, Ramos, Barcola

> Click here to see how Barcelona could line up for this game