The tie is scheduled to take place at the Estadio da Luz in Lisbon and will be contested over one leg.
PSG have won all three domestic trophies on offer this term, most recently beating Lyon on penalties in the Coupe de la Ligue final, and are desperate to make it a clean sweep.
Here, Sports Mole looks at how the French champions could line up against Atalanta in midweek.
Thomas Tuchel was dealt a major blow ahead of this match with Atalanta following the news that injured midfielder Marco Verratti may miss the remainder of the tournament.
In better news, however, influential striker Kylian Mbappe returned to training ahead of schedule this week and has an outside chance of being fit.
Mbappe seems certain to play a role from the bench at best, however, while Angel di Maria is definitely out through suspension, so Tuchel is expected to revert from his favoured 4-4-2 to a 4-3-3.