While the upcoming UEFA Nations League fixtures with Bosnia-Herzegovina and Italy will take priority, De Boer has a chance to assess his squad against El Tri later this week.
Here, Sports Mole predicts how the Netherlands could line up against opponents whom they last played in 2014.
Despite possessing a desire to field his strongest XI, De Boer must take into consideration the individual circumstances of several of his key men.
Captain Virgil van Dijk started three matches for Liverpool last week, leaving it likely that the centre-back will be rested for this contest.
Memphis Depay could also be named among the replacements at a time when he has been left to resolve his future on the club scene.
Club teammate Teun Koopmeiners may also make his first senior outing for Netherlands after several key players represented their clubs on Sunday.