The Lions were expected to be embroiled in a battle against the drop this season, but Fulham find themselves in a somewhat surprising position given their relegation from the Premier League just last season.
The Cottagers are only five points clear of the bottom three - a gap that could be cut to two this weekend - and are without a win in six matches in all competitions going into this game.
Kit Symons's men have picked up just one point from the last 12 available in the Championship and, even more worryingly, have lost their last four away games in the league.
Indeed, only two teams have amassed fewer points on their travels all season, while none have conceded more than the 35 away goals Fulham have shipped in just 15 games.
However, there were positives to take from their last outing despite it ending in defeat as Fulham pushed for a late equaliser against high-flying Ipswich Town, only to go down 2-1 at Craven Cottage in the end.
Ipswich's fellow playoff contenders Wolverhampton Wanderers, Derby County, Watford and Bournemouth are next up for the Cottagers, making this weekend's derby with Millwall even more important.
Confusion continues to reign over the future of Bryan Ruiz, but the Costa Rica international did come off the bench last weekend and could play from the start on Saturday despite reports linking him with a move to Brazil.
Tim Hoogland is still not quite fit enough to start following a long-term injury, but Scott Parker should continue in midfield having returned against Ipswich, while Ross McCormack and Hugo Rodallega are expected to lead the line.
For Millwall, victory could lift them above Brighton & Hove Albion and out of the bottom three, and they will fancy their chances of getting something out of the match considering their recent improvement.
The Lions have won two of their last four games, both against teams in the top half of the table, having not won in nine outings before that.
Both of those victories came away from home, however, and it is at The Den where Millwall's major problems have arisen this season. They have the worst home record in terms of both points won and goals conceded in the division, while they haven't won a match in front of their own fans since October - nine games ago.
A deflected Alex Mowatt goal was all that separated Leeds United from Millwall last weekend, but Ian Holloway will be forced into at least one change from that match due to an injury sustained by Shaun Cummings.
Recent form: LDWLWL
Possible starting lineup: Forde; Beevers, Dunne, Hooiveld, Harding; Williams, Martinez, Martin, Fabbrini, Woolford; Maierhofer
Form in Championship: WWLDLL
Form in all competitions: DLLDLL
Possible starting lineup: Bettinelli; Richards, Hutchinson, Bodurov, Stafylidis; Christensen, Parker, Ruiz, Tunnicliffe; Rodallega, McCormack
Sports Mole says: 0-1