United will be hoping to avoid consecutive home defeats in the league for the first time since May 2002.
Southampton have moved up to fourth place after winning their last three league games, the latest coming against Swansea City two weeks ago. The Saints could go top if they win and other results go their way.
Moyes may be tempted to hand a start to youngster Adnan Januzaj after his brace against Sunderland.
Southampton left-back Luke Shaw could replace Danny Fox in the team after recovering from an illness.
Man Utd: DLWLLW
Possible starting lineups
Man Utd: De Gea; Rafael, Ferdinand, Vidic, Evra; Carrick, Fellaini; Nani, Rooney, Januzaj; Van Persie
Southampton: Boruc; Clyne, Fonte, Lovren, Shaw; Lallana, Schneiderlin, Wanyama, Ward-Prowse; Lambert, Osvaldo
Sports Mole says: 2-1