The group stages of the Champions League concluded this week, with the final places of the last 16 being confirmed.
Manchester United also fell short courtesy of their 3-2 defeat to RB Leipzig, a result which confirmed Paris Saint-Germain's place in the knockout rounds before their rearranged win over Istanbul Basaksehir, which was postponed on Tuesday night following an alleged racist incident involving one of the officials.
Here, Sports Mole selects its Champions League team of the week for matchday six.
In addition to the battle between Messi and Ronaldo, Tuesday's match between Barcelona and Juventus also saw Messi come up against another legend of modern times in Gianluigi Buffon, and it was the goalkeeper who very much came out on top with seven saves from the Argentine alone.
It is a goal-laden back three in this week's team, with Bayern Munich's Niklas Sule, Dynamo Kiev's Denys Popov and Atletico Madrid's Mario Hermoso all getting on the scoresheet in addition to keeping clean sheets.
The wing-backs were similarly important at the sharp end of the field with Lucas Vazquez helping himself to an assist and hitting the woodwork in Real Madrid's win over Monchengladbach and RB Leipzig's Angelino - on loan from Manchester City - helping to knock Man United out with a goal and an assist.
Bruno Fernandes, Phil Foden, Axel Witsel and Ruud Vormer were also pushing for selection, with the latter particularly unfortunate to miss out having helped himself to a goal and an assist in Club Brugge's draw with Lazio.
It is a star-studded front three even without Ronaldo, whose two goals from the spot at Camp Nou are not enough to earn him a place in this week's team.
Youssef En-Nesyri also misses out despite scoring a brace, with Karim Benzema leading the line having scored both of Madrid's goals in their crucial victory - not to mention coming within the crossbar's width of completing his hat-trick.
PSG's star duo of Neymar and Kylian Mbappe were the first names on this week's teamsheet courtesy of their contribution to the win over Istanbul, with Neymar hitting a hat-trick and Mbappe ending his Champions League drought with a brace.