Chelsea's triumph at Liverpool last weekend means that the Citizens will be crowned champions for a second time in three years if they win their remaining three games.
With home matches against Aston Villa and West Ham United to come, a trip to Goodison Park seems the most likely destination where points could be dropped.
It is a double-edged sword for the Toffees, though, who are still in the top-four race and yet desperately do not want to hand the initiative back to fierce rivals Liverpool in their pursuit of a first title in 24 years.
Should they lose to City on Merseyside, the Gunners would be guaranteed an 18th successive season in Europe's premier competition before they kick a ball against West Bromwich Albion on Sunday.
Injuries have hit the Toffees as the worst possible time, with first-choice central defensive pair Phil Jagielka and Sylvain Distin, as well as free-scoring winger Kevin Mirallas, unlikely to play again this term.
David Silva and Jesus Navas are both carrying knocks and are likely to start on the bench, with James Milner restored on the right to provide cover for the marauding runs of Everton's Leighton Baines.
Everton have only lost two of their last 25 matches at Goodison Park, and have won their last four against City, but Manuel Pellegrini's side have only tasted defeat twice in 24 games.
Man City: WWDLWD
Possible starting lineups
Everton: Howard; Coleman, Stones, Alcaraz, Baines; McCarthy, Osman; Naismith, Barkley, Deulofeu; Lukaku
Man City: Hart; Zabaleta, Kompany, Demichelis, Clichy; Milner, Toure, Fernandinho, Nasri; Dzeko, Aguero
Sports Mole says: 1-3