The Citizens' treble hopes were ended by Pierre-Emerick Aubameyang's brace at Wembley but they must quickly pick themselves up.
Pep Guardiola's sole focus is now on the Champions League, with next month's rearranged last-16 second leg with Real Madrid taking on even more importance.
Ahead of Tuesday's trip to Vicarage Road, Sports Mole rounds up City's latest injury and suspension news.
Type of injury: Knee
Possible return date: Unknown
Sergio Aguero will not feature again in the Premier League this season after undergoing knee surgery in Barcelona last month. There is a chance that the Argentine could be back for part of their Champions League campaign, although it remains to be seen how the striker's recovery progresses in the coming weeks.
Status: Major doubt
Type of injury: Muscular
Possible return date: July 21 (vs. Watford)
Claudio Bravo had played every minute of City's FA Cup campaign this season before missing Saturday's semi-final with a muscular issue. The Chilean may be back among the subs for this trip to Watford.
MANCHESTER CITY'S SUSPENSION LIST
City have no suspension concerns heading into this penultimate Premier League game of the campaign.