Man City head into the contest after securing a 1-1 draw with Stoke City at the weekend but the North West side will be largely relying on the fitness of Sergio Aguero, who has not played since the opening day of the season due to an ankle injury.
City boss Roberto Mancini has confirmed that the Argentina international will travel with the squad to Madrid, which suggests that he will start for the league champions at the Bernabeu alongside Carlos Tevez up front.
Meanwhile, Mourinho has no fresh injury worries heading into the clash, which means that Cristiano Ronaldo, who has cast doubts over his future in recent weeks, is likely to start just behind Karim Benzema.
Real Madrid: LWWL
Manchester City: WDWD
Real Madrid: Casillas; Arbeloa, Ramos, Pepe, Marcelo; Alonso, Khedira; Ozil, Modric, Ronaldo; Benzema
Manchester City: Hart; Maicon, Kompany, Lescott, Clichy; Yaya Toure, Garcia; Silva, Nasri; Tevez, Aguero
Sports Mole says: 1-1