After a valiant effort against Austria, manager Igor Angelovski may decide to stick with the same starting lineup in Bucharest.
The 45-year-old could be tempted to use a more attack-minded formation, as he has done in previous matches this year, but the 3-5-2 formation, which was used on Sunday, is the setup he will most likely stick with.
Key duo Aleksandar Trajkovski and Ezgjan Alioski both received yellow cards in the opening game and are now just one booking away from a suspension. Nevertheless, both players are set to start up front and at left wing-back respectively.
Trajkovski is set to be joined in attack by captain Goran Pandev, who scored North Macedonia's first ever goal at a major tournament against Austria, and the 37-year-old also became the second oldest goalscorer at the European Championships.
North Macedonia possible starting lineup: Dimitrievski; S.Ristevski, Velkovski, Musliu; Nikolov, Bardhi, Ademi, Elmas, Alioski; Pandev, Trajkovski