The home team came out on top in each of the three previous meetings, including a 2-1 win at the Campbelltown Stadium on May 27.
Central Coast Mariners defeated Western United 2-0 in their final A-league regular season fixture on Saturday.
The Mariners now prepare for their first playoff appearance since the 2013/14 campaign, when they were beaten in the semi-final by Western Sydney Wanderers.
Saturday's hosts finished bottom in four of the next five seasons before the appointment of Alen Stajcic on a full-time basis in May 2019.
They finished with the third-best defence in the regular season and will bank on that solidity at the back for a deep run into the post-season.
Macarthur FC ended their campaign with a 3-0 defeat against Wellington Phoenix on Friday.
The Bulls finished sixth in their debut season in the Australian top flight, but ended the season with only one win in the last four games.
Saturday's visitors also conceded the most goals of any team in the playoffs, which is an area that needs improvement if they are to excel at this level.
Thirty-five-year-old Matt Simon is without a goal in his last four appearances for the hosts, which is his longest drought of the campaign.
Alongside Daniel De Silva, the duo have been responsible for three of the six goals scored by Central Coast Mariners against their visitors since the turn of the year.
Matt Derbyshire was involved in 19 of Macarthur's 33 goals during the regular season, making him their most influential player by a fair distance.
Loic Puyo will serve the first of a three-game suspension in this one after he was given his marching orders last time out.
Central Coast Mariners possible starting lineup:
Birighitti; Clisby, Rowles, Hall, Miller; Casella, Nisbet, Bouman, Balard; Kuol, Simon
Macarthur possible starting lineup:
Federechi; Meredith, Susnjar, McGing, Franjic; Milligan, Martis, M'Monbwa; Oar, Najjar, Ruhs
We say: Central Coast Mariners 2-0 Macarthur
The visitors have punched considerably above their weight since their promotion, but we are backing the hosts to emerge victorious in this one due to their level of experience at this stage.