Jan Vertonghen has already been ruled out while Vlad Chiriches and Younes Kaboul are doubts, and Villas-Boas also has to decide whether to recall Roberto Soldado to Premier League action after his hat-trick in the Europa League on Thursday.
Spurs have responded well to their 6-0 drubbing by Manchester City to win four of their next five matches.
Tottenham Hotspur: LWDWWW
Possible starting lineups
Tottenham Hotspur: Lloris; Walker, Naughton, Capoue, Dawson; Dembele, Lennon, Paulinho, Townsend, Sigurdsson; Defoe
Liverpool: Mignolet; Johnson, Flanagan, Skrtel, Agger; Allen, Henderson, Lucas, Coutinho, Moses; Suarez
Sports Mole says: 1-2