Los Blancos travel to Anfield boasting a 3-1 lead from the first leg, but Zidane lost makeshift right-back Lucas Vazquez to injury during El Clasico at the weekend, and the soon-to-be free agent has been ruled out for the foreseeable with a cruciate ligament sprain.
With Dani Carvajal not ready to return from a hamstring problem, Alvaro Odriozola - only just back from injury himself - is set to occupy the right-hand side as he does his best to keep Sadio Mane quiet on Merseyside.
Sergio Ramos has not recovered from a calf problem and recently contracted COVID-19, while Raphael Varane returned a positive coronavirus test before the first leg, so Nacho Fernandez and Eder Militao are set to form the centre-back pairing on Wednesday.
Casemiro's red card in El Clasico does not affect his participation here, and the Brazilian will once again line up with Toni Kroos - who shone in the first leg - and Luka Modric, who could make history for Real Madrid if he registers an assist for the fourth Champions League game in a row.
Karim Benzema will lead the line as he looks to build on the four strikes he already boasts against Liverpool, while the hero of the first leg - Vinicius Junior - will complete Zidane's front three as the injury-plagued Eden Hazard remains out of action.
Real Madrid possible starting lineup:
Courtois; Odriozola, Nacho, Militao, Mendy; Casemiro, Kroos, Modric; Asensio, Benzema, Vinicius Jr