The Serbia midfielder has emerged as one of the most sought-after players in Europe, with Manchester United having previously been linked with his services.
Milinkovic-Savic scored 13 goals and registered nine assists in 45 appearances for the Biancocelesti last season, before going on to represent his country at the World Cup.
When asked by Italian outlet Mediaset about the 23-year-old's future at the Stadio Olimpico, Lotito replied: "I have not put Milinkovic-Savic up for sale. If any indecent [outrageous] offers arrive, they will be considered."
Manchester City, Chelsea and Real Madrid have also been linked with the Spain-born player.