President of the Italian FA, Giancarlo Abete, later said that he hoped Prandelli would rethink the decision, but the former Roma coach will stand by his choice.
"I talked to the president of the Federation and Demetrio Albertini, and gave my resignation. The technical setup didn't work, and I take all responsibility for that.
"Something has changed since my contract was renewed. I don't know why. I chose a certain technical plan and that's why I am resigning, because it did not work. My resignation is irrevocable."
Prandelli led Italy to the final of Euro 2012.