The duo, of Liverpool and Chelsea, will shoulder plenty of the burden for the Super Eagles as they look to get an early win under their belt in Group F.
Chelsea's Kenneth Omeruo, meanwhile, starts in defence for the African side.
Iran: Haghighi; Heydari, Haji Safi, Hosseini, Sadeghi; Nekounam, Teymourian, Montazeri, Ghoochannejad, Dejagah; Pooladi
Nigeria: Enyeama; Ambrose, Oshaniwa, Oboabona, Omeruo; Mikel, Onazi, Azeez, Musa, Moses; Emenike
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