Antonio Conte's side have work to do if they are to progress as Napoli hold a 1-0 advantage from the first leg of their last-four clash at San Siro back in February.
Inter have not been in action since losing 2-0 to Juventus in Serie A on March 8 due to the coronavirus outbreak, but European football is slowly returning following a lengthy absence.
Here, Sports Mole looks at how Inter could line up for their first game back.
Out: Daniele Padelli (suspension)
Daniele Padelli will be unavailable for Inter through suspension, but Conte's squad is otherwise in excellent shape heading into the second leg of their semi-final.
Experienced defender Diego Godin was left on the bench against Juve last time out but is expected to return to the XI for this match, while Christian Eriksen could also earn a spot in the starting side.
On-loan Manchester United attacker Alexis Sanchez is another option having overcome an ankle injury, although it is unlikely that either Romelu Lukaku or Lautaro Martinez will be left out in the final third of the field.