The Terriers will be full of confidence having ended Burnley's 12-match unbeaten league run with a 2-1 win over the Clarets at the John Smith's Stadium on Saturday.
Newly-acquired loanee Joe Mason, who arrived on a temporary deal from Cardiff City this week, could be handed his first Trotters start after making a seven-minute cameo off the bench against Boro.
He is likely to be paired with former Terrier Jermaine Beckford, who scored nine goals during his spell with Huddersfield last season, in attack if Freedman opts to switch to a 4-4-2 formation.
In Beckford's absence, James Vaughan has shone for the Yorkshire outfit this term and is the division's joint-third top goalscorer with 10. Manager Mark Robins will choose between Sean Scannell and Martin Paterson as his strike partner.
Possible starting lineups:
Bolton: Lonergan; McNaughton, Ream, Baptiste, Mills; Spearing, Danns, Prately, Chung-Yong; Mason, Beckford
Huddersfield: Smithies; Smith, Lynch, Gerrard, Dixon; Hammill, Norwood, Clayton, Hogg, Vaughan, Scannell
Sports Mole says: 1-1