Hoffenheim were able to secure a hard-fought draw away to Red Star Belgrade last time out, while Gent were beaten for the fifth consecutive game in this year's competition, this time at the hands of Slovan Liberec.
Four wins and one draw has seen the German side go three points clear at the top of the group, and even if they lose on Thursday they are already guaranteed top spot due to their superior head-to-head record over Red Star Belgrade.
Hoffenheim and Gent met earlier in the campaign, with Hoffenheim running out 4-1 winners in their first-ever meeting in any competition.
In that same match, Hoffenheim conceded the only goal that has been scored against them in this year's tournament, and after shipping 10 goals in their last Europa League group stage campaign, Hoffenheim look set to become the first German team to concede fewer than two goals in this stage of the competition.
From Gent's perspective, it has been a European campaign to forget, having lost all five games to date and shipping 11 goals in that time. Unfortunately for the Belgian side, their poor form goes beyond this year's competition.
Gent have lost their last seven matches in all European competitions, including qualifiers, and this is the worst losing run by a Belgian team in Europe.
Gent's away form does not make for better reading, seeing as they are currently on their worst run of away form since 2010, having lost their last three away fixtures,
It is not all doom and gloom, though. The last time they traveled to face a German team, they emerged victorious after turning over a Wolfsburg side 3-1 in the group stage of last season's Europe League.
With nothing to play for, Wim De Decker will be hoping his side can find a positive result to take back into their domestic season, where they are also winless in their last five matches.
Hoffenheim Europa League form: WWWWD
Hoffenheim form (all competitions): LDWDDW
Gent Europa League form: LLLLL
Gent form (all competitions): DLLLLL
For De Decker, Igor Plastun and Roman Yaremchuk could return to the starting lineup after suffering from COVID-19. Still, they will likely start from the bench as the Belgian side turn their attention to domestic football.
Other than a hamstring injury for Alexandre De Bruyn, De Decker has no fresh injury concerns for Hoffenheim's trip.
Hoffenheim possible starting lineup:
Baumann; Bogarde, Kasim, Nordtveit, Skov; Rudy, Vogt, Geiger, Gacinovic; Beier, De Mello
Gent possible starting lineup:
Bolat; Hanche-Olsen, Ngadeu-Ngadjui, Fortuna; Botaka, Dorsch, Owusu, Kums, Mohammadi; Bukari, Bezus
We say: Hoffenheim 2-0 Gent
Despite both sides resting key players, we see this game going in the same direction as the reverse fixture with a convincing win for Hoffenheim. We expect Hoffenheim to finish the group stage in the same way they started, with a win to keep them top of the group.