The Paris-Saint Germain star will play in an advanced midfield position, providing support for Sandro Wagner.
San Marino goalkeeper Elia Benedettini, who plays his club football for Novara, is one of three Italy-based players in the visitors' lineup, along with Pier Filippo Mazza of Sant'Ermete Calcio and Tropical Coriano's Alessandro Golinucci, both of whom start in midfield.
Germany: ter Stegen, Mustafi, Hector, Draxler, Goretzka, Wagner, Stindl, Can, Younes, Kimmich, Brand
Subs: Rudy, Trapp, Plattenhardt, Leno, Demme, Rudiger, Ginter, Sule, Demirbay, Werner, Henrichs
San Marino: Benedettini, Biordi, Valle, Cervellini, Cesarini, Bonini, Zafferani, Mazza, Palazzi, Golinucci, Rinaldi
Subs: Vitaioli, Berretti, Simoncini, Hirsch, Brolli, Manzaroli, Tosi, Golinucci, Bernardi, Cevoli