The hosting Germans will be without two of their key players for the visit of Paraguay on Wednesday night.
Low has also lost the services of Schalke 04 attacker Julian Draxler, who picked up an Achilles injury at the weekend.
However, Chelsea's summer signing Andre Schurrle was named in the squad and has been tipped to start in attack.
Meanwhile, former Manchester City and Blackburn Rovers centre-forward Roque Santa Cruz should be named in the away side's starting lineup.
Germany: Neuer; Schmelzer, Hummels, Boateng, Lahm; Khedira, Gundogan, Ozil, Reus, Schurrle; Gomez
Paraguay: Villar; Da Silva, Aguilar, Samudio, Candia; Riveros, Martinez, Ortiz, Fabbro; Santa Cruz, Benitez
Sports Mole says: 3-1