The Three Lions took the lead within the opening three minutes against Moldova on Friday night and as a result went on to win the match 5-0.
With that in mind, Manchester City's Milner believes that a quick goal could prove vital against a nation that England recently faced at Euro 2012.
"It will be slightly different but the majority of the squads will be very similar," he said. "This time it is on our home turf and we need to make sure we put in a good performance, they showed over the summer they are no pushovers - they are a strong side with a number of good players.
"We need to be on the top of our game. Hopefully we can get an early goal again, settle down and play some football."
Milner's goal during the Moldova clash was his first at senior international level.