Cedric Soares is also back in the fold at right-back as the Saints look to move as high as fifth in the Premier League table with a win over the champions.
Meanwhile, interim Chelsea manager Guus Hiddink makes two alterations from the side that thumped Newcastle United 5-1 last time out.
January signing Alexandre Pato has made the trip to the south coast with his new side but plays no part in the matchday squad as he continues to build up his fitness.
Southampton: Forster; Cedric, Fonte, Van Dijk, Targett; Long, Romeu, Davis, Clasie, Bertrand; Austin
Subs: Stekelenburg, Yoshida, Mane, Tadic, Martina, Ward-Prowse, Pelle
Chelsea: Courtois; Azpilicueta, Cahill, Ivanovic, Baba Rahman; Mikel, Fabregas; Pedro, Willian, Hazard; Diego Costa
Subs: Begovic, Matic, Loftus-Cheek, Kenedy, Oscar, Traore, Remy
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