The Saints have defeated both Manchester City and Liverpool in the past two months, and a third win would see them move clear of the relegation zone.
Chelsea boss Rafael Benitez would have been encouraged by his team's form before the international break.
However, he could be forced into rotating his side ahead of a hectic fixture list that sees them play four times in a week.
Possible starting lineups
Southampton: Boruc; Clyne, Yoshida, Fonte, Shaw; Schneiderlin, Ramirez, Cork, Lallana; Lambert, Rodriguez
Chelsea: Cech; Cole, David Luiz, Ivanovic, Azpilicueta; Ramires, Lampard, Mata, Moses, Hazard; Torres
Sports Mole says: 1-2