The Blues go into the match having seen their grip on the final Champions League spot diminish in recent weeks courtesy of a run of four defeats in their last five league outings.
Spurs have been in contrasting form, winning four of five since Mourinho's appointment, leaving just three points between the two sides ahead of this London derby.
Here, Sports Mole looks at how Chelsea could line up for the contest.
Lampard is expected to have Fikayo Tomori back available after a hip injury kept him out of the last two squads, although the young defender's place in the team has come under threat following Antonio Rudiger's return to fitness.
Rudiger and Kurt Zouma have been the preferred centre-back partnership in the last couple of games and should start alongside each other once again unless Lampard chooses to shake things up due to his side's poor recent form.
Olivier Giroud should also be available to Lampard, although the Frenchman is firmly behind Tammy Abraham in the pecking order and the England international will lead the line again.
Abraham has 11 goals in 16 league outings so far this season, leaving above compatriot Harry Kane in the scoring charts ahead of the two meeting in this match.