Xabi Alonso faces a major selection dilemma over whether to start Enzo Fernandez amid lingering doubts regarding the Chelsea midfielder's long-term future in the capital.
The Spanish tactician may well decide against thrusting the Argentina international into the lineup from the off, with Romeo Lavia instead set to be rewarded with a start alongside Moises Caicedo following an impressive pre-season campaign.
Lavia and Caicedo are expected to anchor the engine room, flanked by Pedro Neto and Marco Palestra in the wing-back positions to provide width in Alonso's setup.
Further forward, British record signing Morgan Rogers is poised to feature in tandem with Cole Palmer, whose creative burden should be considerably eased after a below-par campaign blighted by fatigue and injuries.
The creative duo will be tasked with supplying leading marksman Joao Pedro, who recently committed his future to the club until 2032 and carries momentum into the new term after netting seven goals in pre-season.
On the team news front, Danny Welbeck faces a late fitness assessment, while Jordan Henderson and Emmanuel Emegha are definitely ruled out for the short trip to Craven Cottage.
The visitors are also condemned to cope without suspended centre-back Wesley Fofana following his dismissal on the final day of the previous season, opening the door for new signing Maxence Lacroix to partner Levi Colwill and captain Reece James in a three-man rearguard.
This defensive trio will line up directly in front of goalkeeper Robert Sanchez, who is set to retain the gloves between the sticks as Chelsea kick off their domestic campaign.
Chelsea possible starting lineup:
Sanchez; James, Lacroix, Colwill; Neto, Caicedo, Lavia, Palestra; Palmer, Rogers; Joao Pedro
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