Mourinho will be facing QPR for the first time, and despite their recent struggles in the Premier League, the Portuguese coach has insisted that he is anticipating a difficult game at Stamford Bridge.
The 51-year-old told reporters: "I think that I know what to expect from QPR, and I can say it will be a difficult game for us.
"It's the first time that I play against QPR. London is a special place because of the number of derbies, which makes it unique."
Chelsea currently possess a four-point advantage at the top of the Premier League table.