On-loan Everton defender Matthew Pennington picked up a groin strain in training on Thursday, with scans required to determine the extent of the problem.
However, the Tigers could be boosted by the return of defender Stephen Kingsley, who is back in training after three weeks out, while forward Kamil Grosicki is also closing in on a comeback after injury.
Tammy Abraham will be a doubt for Chelsea ahead of the trip north after suffering an ankle injury scare against Arsenal on Tuesday night.
The England striker hobbled off the Stamford Bridge turf at full-time in the 2-2 Premier League draw.
Ruben Loftus-Cheek remains a long-term absentee after heel surgery.