One of those to profit from the rotation is January signing Emerson Palmieri, who comes in for his debut and just a third appearance of any sort this season.
As far as the visitors are concerned, Nigel Adkins is without as many as 12 first-team players due to injury and therefore makes seven changes from the 2-0 win at Nottingham Forest last weekend.
David Marshall, David Meyler, Michael Dawson, Kevin Stewart, Evandro, Adama Diomande and Nouha Dicko are all included from the off, as the Tigers - fourth-bottom in the Championship - seek a third win of 2018.
Chelsea: Caballero; Rudiger, Cahill, Ampadu; Zappacosta, Drinkwater, Fabregas, Emerson; Willian, Giroud, Pedro
Subs: Eduardo, Chalobah, Sterling, Scott, Moses, Hudson-Odoi, Morata
Hull City: Marshall, Irvine, Meyler, Dicko, Diomande, Evandro, Dawson, Clark, Stewart, Wilson, Macdonald
Subs: McGregor, Grosicki, Toral, Batty, Keane, Campbell, Clackstone
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