However, if Rubin are to progress, they will have to become the first Russian side to ever defeat the Blues. The English outfit have won all five of their encounters against teams from the Eastern European nation, conceding just two goals in the process.
As he has done so often this season, interim manager Rafael Benitez is likely to shuffle his squad around for this contest. Captain John Terry should be included, while Fernando Torres will lead the attack in the absence of the cup-tied Demba Ba.
Meanwhile, hosting Rubin could start with former Malaga centre-forward Salomon Rondon in attack.
Possible starting lineups
Rubin: Ryzhikov; Navas, Kuzmin, Kaleshin, Ansaldi; Sharonov, Orbaiz, Eremenko, Natcho; Dyadyun, Rondon
Chelsea: Cech; Ivanovic, Terry, Luiz, Bertrand; Mikel, Lampard; Moses, Oscar, Mata; Torres
Sports Mole says: 2-1