PAOK, who finished second in the Greek top flight last season, last faced English opposition during the 2011-12 Europa League, and actually beat Tottenham Hotspur in London during that particular campaign.
The team also held Spurs to a goalless draw in the home match and have previously beaten Premier League opposition in the shape of Arsenal during the 1997-98 UEFA Cup.
Razvan Lucescu's side will enter the match having won three of their last four matches in all competitions, but the defeat during that run - at home to Benfica - saw them fail to make the group stage of the Champions League.
PAOK will now be firmly focused on making an impression in the Europa League, however, as they prepare to welcome Chelsea on Thursday night.
Here, Sports Mole looks at how the home side could line up in front of their own fans.
Doubtful: Aleksandar Prijovic (hamstring)
PAOK's main selection dilemma entering the clash with Chelsea comes in the final third, with head coach Lucescu debating whether to select Aleksandar Prijovic.
The Serbian, who has five goals in eight matches this season, picked up a hamstring problem during a training session last week, and missed his team's 3-1 win over OFI Crete in the Greek Super League on Saturday.
The 28-year-old was expected to miss the clash with the Blues but took part in a training session on Monday, and he could now be handed a spot in the final third of the field.