Owen Coyle's side – who were relegated from the Premier League last season – opened the new season with a disappointing 2-0 defeat to Burnley at Turf Moor. Meanwhile, Derby surrendered a two-goal lead to draw 2-2 with Sheffield Wednesday at Pride Park.
The last time the two sides met was in the Premier League in January 2008 when Bolton claimed all three points in a 1-0 win, but the Trotters have won just two of their last seven meetings with the Rams.
Both sides have no fresh injury concerns to contend with ahead of the encounter, although Bolton could hand a start to former Manchester United midfielder Chris Eagles.
Bolton: Bogdan; Mears, Ream, Knight, Ricketts; Lee, Davies, Andrews, Petrov; Sordell, Davies
Derby: Fielding; Brayford, Keogh, Buxton, Roberts; Coutts, Hendrick, Bryson, Hughes; Tyson, Ward
Sports Mole says: 2-0